positive control rain plots Search Results


positive control rain plots  (Bio-Rad)
91
Bio-Rad positive control rain plots
Positive Control Rain Plots, supplied by Bio-Rad, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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nanostring g positive controls  (Bruker Corporation)
96
Bruker Corporation nanostring g positive controls
Nanostring G Positive Controls, supplied by Bruker Corporation, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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sodium perchlorate  (Millipore)
97
Millipore sodium perchlorate
Sodium Perchlorate, supplied by Millipore, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ppp1r13l protein  (Proteintech)
93
Proteintech ppp1r13l protein
List of robust exome-by-phenome-wide significant gene-phenotype associations. List of genes among 97 pLOF-based gene burdens with phenotype associations at P < 10 −6 in the PMBB discovery cohort that were most robust according to the DiCE approach, which integrates successful replication of the association with clinical and experimental evidence. For replication studies, gene–phenotype associations were evaluated for their robustness by interrogating REVEL-informed missense-based gene burdens and single variants in the same discovery PMBB cohort, and pLOF-based gene burdens, REVEL-informed missense-based gene burdens and single variants in an independent cohort of African Americans in the PMBB (the PMBB2 cohort), as well as in BioMe, DiscovEHR and the UKB. Targeted single variants that showed successful replication in the PMBB, PMBB2 and UKB were additionally analyzed in BioVU. Each gene–phecode association is labeled with the corresponding P value from logistic regression analyses in the discovery phase in the PMBB, as well as the number of total replications and existence of clinical/experimental evidence, fully detailed in Supplementary Table 17 . Only associations with at least two total check marks in Supplementary Table 17 , where each successful mode of replication in a particular biobank (for example, pLOF burden in BioMe) or the existence of clinical/experimental evidence is labeled with a checkmark, were deemed robust and therefore included here. Previously known associations were considered to represent positive controls. Positive control (above line) and new associations (below line) are each ranked alphabetically by gene name.
Ppp1r13l Protein, supplied by Proteintech, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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rainn n-hour rain accumulation  (Vaisala Inc)
90
Vaisala Inc rainn n-hour rain accumulation
List of robust exome-by-phenome-wide significant gene-phenotype associations. List of genes among 97 pLOF-based gene burdens with phenotype associations at P < 10 −6 in the PMBB discovery cohort that were most robust according to the DiCE approach, which integrates successful replication of the association with clinical and experimental evidence. For replication studies, gene–phenotype associations were evaluated for their robustness by interrogating REVEL-informed missense-based gene burdens and single variants in the same discovery PMBB cohort, and pLOF-based gene burdens, REVEL-informed missense-based gene burdens and single variants in an independent cohort of African Americans in the PMBB (the PMBB2 cohort), as well as in BioMe, DiscovEHR and the UKB. Targeted single variants that showed successful replication in the PMBB, PMBB2 and UKB were additionally analyzed in BioVU. Each gene–phecode association is labeled with the corresponding P value from logistic regression analyses in the discovery phase in the PMBB, as well as the number of total replications and existence of clinical/experimental evidence, fully detailed in Supplementary Table 17 . Only associations with at least two total check marks in Supplementary Table 17 , where each successful mode of replication in a particular biobank (for example, pLOF burden in BioMe) or the existence of clinical/experimental evidence is labeled with a checkmark, were deemed robust and therefore included here. Previously known associations were considered to represent positive controls. Positive control (above line) and new associations (below line) are each ranked alphabetically by gene name.
Rainn N Hour Rain Accumulation, supplied by Vaisala Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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hmp75c temperature and humidity probe  (Vaisala Inc)
90
Vaisala Inc hmp75c temperature and humidity probe
List of robust exome-by-phenome-wide significant gene-phenotype associations. List of genes among 97 pLOF-based gene burdens with phenotype associations at P < 10 −6 in the PMBB discovery cohort that were most robust according to the DiCE approach, which integrates successful replication of the association with clinical and experimental evidence. For replication studies, gene–phenotype associations were evaluated for their robustness by interrogating REVEL-informed missense-based gene burdens and single variants in the same discovery PMBB cohort, and pLOF-based gene burdens, REVEL-informed missense-based gene burdens and single variants in an independent cohort of African Americans in the PMBB (the PMBB2 cohort), as well as in BioMe, DiscovEHR and the UKB. Targeted single variants that showed successful replication in the PMBB, PMBB2 and UKB were additionally analyzed in BioVU. Each gene–phecode association is labeled with the corresponding P value from logistic regression analyses in the discovery phase in the PMBB, as well as the number of total replications and existence of clinical/experimental evidence, fully detailed in Supplementary Table 17 . Only associations with at least two total check marks in Supplementary Table 17 , where each successful mode of replication in a particular biobank (for example, pLOF burden in BioMe) or the existence of clinical/experimental evidence is labeled with a checkmark, were deemed robust and therefore included here. Previously known associations were considered to represent positive controls. Positive control (above line) and new associations (below line) are each ranked alphabetically by gene name.
Hmp75c Temperature And Humidity Probe, supplied by Vaisala Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/hmp75c temperature and humidity probe/product/Vaisala Inc
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ein markstein der keltischen archäologie  (Markstein Sichtec Medical)
90
Markstein Sichtec Medical ein markstein der keltischen archäologie
List of robust exome-by-phenome-wide significant gene-phenotype associations. List of genes among 97 pLOF-based gene burdens with phenotype associations at P < 10 −6 in the PMBB discovery cohort that were most robust according to the DiCE approach, which integrates successful replication of the association with clinical and experimental evidence. For replication studies, gene–phenotype associations were evaluated for their robustness by interrogating REVEL-informed missense-based gene burdens and single variants in the same discovery PMBB cohort, and pLOF-based gene burdens, REVEL-informed missense-based gene burdens and single variants in an independent cohort of African Americans in the PMBB (the PMBB2 cohort), as well as in BioMe, DiscovEHR and the UKB. Targeted single variants that showed successful replication in the PMBB, PMBB2 and UKB were additionally analyzed in BioVU. Each gene–phecode association is labeled with the corresponding P value from logistic regression analyses in the discovery phase in the PMBB, as well as the number of total replications and existence of clinical/experimental evidence, fully detailed in Supplementary Table 17 . Only associations with at least two total check marks in Supplementary Table 17 , where each successful mode of replication in a particular biobank (for example, pLOF burden in BioMe) or the existence of clinical/experimental evidence is labeled with a checkmark, were deemed robust and therefore included here. Previously known associations were considered to represent positive controls. Positive control (above line) and new associations (below line) are each ranked alphabetically by gene name.
Ein Markstein Der Keltischen Archäologie, supplied by Markstein Sichtec Medical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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rain gauges vaisala  (Vaisala Inc)
90
Vaisala Inc rain gauges vaisala
List of robust exome-by-phenome-wide significant gene-phenotype associations. List of genes among 97 pLOF-based gene burdens with phenotype associations at P < 10 −6 in the PMBB discovery cohort that were most robust according to the DiCE approach, which integrates successful replication of the association with clinical and experimental evidence. For replication studies, gene–phenotype associations were evaluated for their robustness by interrogating REVEL-informed missense-based gene burdens and single variants in the same discovery PMBB cohort, and pLOF-based gene burdens, REVEL-informed missense-based gene burdens and single variants in an independent cohort of African Americans in the PMBB (the PMBB2 cohort), as well as in BioMe, DiscovEHR and the UKB. Targeted single variants that showed successful replication in the PMBB, PMBB2 and UKB were additionally analyzed in BioVU. Each gene–phecode association is labeled with the corresponding P value from logistic regression analyses in the discovery phase in the PMBB, as well as the number of total replications and existence of clinical/experimental evidence, fully detailed in Supplementary Table 17 . Only associations with at least two total check marks in Supplementary Table 17 , where each successful mode of replication in a particular biobank (for example, pLOF burden in BioMe) or the existence of clinical/experimental evidence is labeled with a checkmark, were deemed robust and therefore included here. Previously known associations were considered to represent positive controls. Positive control (above line) and new associations (below line) are each ranked alphabetically by gene name.
Rain Gauges Vaisala, supplied by Vaisala Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rain gauges vaisala/product/Vaisala Inc
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character string  (Amega Biotech)
90
Amega Biotech character string
List of robust exome-by-phenome-wide significant gene-phenotype associations. List of genes among 97 pLOF-based gene burdens with phenotype associations at P < 10 −6 in the PMBB discovery cohort that were most robust according to the DiCE approach, which integrates successful replication of the association with clinical and experimental evidence. For replication studies, gene–phenotype associations were evaluated for their robustness by interrogating REVEL-informed missense-based gene burdens and single variants in the same discovery PMBB cohort, and pLOF-based gene burdens, REVEL-informed missense-based gene burdens and single variants in an independent cohort of African Americans in the PMBB (the PMBB2 cohort), as well as in BioMe, DiscovEHR and the UKB. Targeted single variants that showed successful replication in the PMBB, PMBB2 and UKB were additionally analyzed in BioVU. Each gene–phecode association is labeled with the corresponding P value from logistic regression analyses in the discovery phase in the PMBB, as well as the number of total replications and existence of clinical/experimental evidence, fully detailed in Supplementary Table 17 . Only associations with at least two total check marks in Supplementary Table 17 , where each successful mode of replication in a particular biobank (for example, pLOF burden in BioMe) or the existence of clinical/experimental evidence is labeled with a checkmark, were deemed robust and therefore included here. Previously known associations were considered to represent positive controls. Positive control (above line) and new associations (below line) are each ranked alphabetically by gene name.
Character String, supplied by Amega Biotech, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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rain gauge caipos rain gauge  (Caipos GmbH)
90
Caipos GmbH rain gauge caipos rain gauge
List of robust exome-by-phenome-wide significant gene-phenotype associations. List of genes among 97 pLOF-based gene burdens with phenotype associations at P < 10 −6 in the PMBB discovery cohort that were most robust according to the DiCE approach, which integrates successful replication of the association with clinical and experimental evidence. For replication studies, gene–phenotype associations were evaluated for their robustness by interrogating REVEL-informed missense-based gene burdens and single variants in the same discovery PMBB cohort, and pLOF-based gene burdens, REVEL-informed missense-based gene burdens and single variants in an independent cohort of African Americans in the PMBB (the PMBB2 cohort), as well as in BioMe, DiscovEHR and the UKB. Targeted single variants that showed successful replication in the PMBB, PMBB2 and UKB were additionally analyzed in BioVU. Each gene–phecode association is labeled with the corresponding P value from logistic regression analyses in the discovery phase in the PMBB, as well as the number of total replications and existence of clinical/experimental evidence, fully detailed in Supplementary Table 17 . Only associations with at least two total check marks in Supplementary Table 17 , where each successful mode of replication in a particular biobank (for example, pLOF burden in BioMe) or the existence of clinical/experimental evidence is labeled with a checkmark, were deemed robust and therefore included here. Previously known associations were considered to represent positive controls. Positive control (above line) and new associations (below line) are each ranked alphabetically by gene name.
Rain Gauge Caipos Rain Gauge, supplied by Caipos GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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handbook of the law of armed conflict  (Routledge Ltd)
90
Routledge Ltd handbook of the law of armed conflict
List of robust exome-by-phenome-wide significant gene-phenotype associations. List of genes among 97 pLOF-based gene burdens with phenotype associations at P < 10 −6 in the PMBB discovery cohort that were most robust according to the DiCE approach, which integrates successful replication of the association with clinical and experimental evidence. For replication studies, gene–phenotype associations were evaluated for their robustness by interrogating REVEL-informed missense-based gene burdens and single variants in the same discovery PMBB cohort, and pLOF-based gene burdens, REVEL-informed missense-based gene burdens and single variants in an independent cohort of African Americans in the PMBB (the PMBB2 cohort), as well as in BioMe, DiscovEHR and the UKB. Targeted single variants that showed successful replication in the PMBB, PMBB2 and UKB were additionally analyzed in BioVU. Each gene–phecode association is labeled with the corresponding P value from logistic regression analyses in the discovery phase in the PMBB, as well as the number of total replications and existence of clinical/experimental evidence, fully detailed in Supplementary Table 17 . Only associations with at least two total check marks in Supplementary Table 17 , where each successful mode of replication in a particular biobank (for example, pLOF burden in BioMe) or the existence of clinical/experimental evidence is labeled with a checkmark, were deemed robust and therefore included here. Previously known associations were considered to represent positive controls. Positive control (above line) and new associations (below line) are each ranked alphabetically by gene name.
Handbook Of The Law Of Armed Conflict, supplied by Routledge Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/handbook of the law of armed conflict/product/Routledge Ltd
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Image Search Results


List of robust exome-by-phenome-wide significant gene-phenotype associations. List of genes among 97 pLOF-based gene burdens with phenotype associations at P < 10 −6 in the PMBB discovery cohort that were most robust according to the DiCE approach, which integrates successful replication of the association with clinical and experimental evidence. For replication studies, gene–phenotype associations were evaluated for their robustness by interrogating REVEL-informed missense-based gene burdens and single variants in the same discovery PMBB cohort, and pLOF-based gene burdens, REVEL-informed missense-based gene burdens and single variants in an independent cohort of African Americans in the PMBB (the PMBB2 cohort), as well as in BioMe, DiscovEHR and the UKB. Targeted single variants that showed successful replication in the PMBB, PMBB2 and UKB were additionally analyzed in BioVU. Each gene–phecode association is labeled with the corresponding P value from logistic regression analyses in the discovery phase in the PMBB, as well as the number of total replications and existence of clinical/experimental evidence, fully detailed in Supplementary Table 17 . Only associations with at least two total check marks in Supplementary Table 17 , where each successful mode of replication in a particular biobank (for example, pLOF burden in BioMe) or the existence of clinical/experimental evidence is labeled with a checkmark, were deemed robust and therefore included here. Previously known associations were considered to represent positive controls. Positive control (above line) and new associations (below line) are each ranked alphabetically by gene name.

Journal: Nature medicine

Article Title: Exome-wide evaluation of rare coding variants using electronic health records identifies new gene-phenotype associations

doi: 10.1038/s41591-020-1133-8

Figure Lengend Snippet: List of robust exome-by-phenome-wide significant gene-phenotype associations. List of genes among 97 pLOF-based gene burdens with phenotype associations at P < 10 −6 in the PMBB discovery cohort that were most robust according to the DiCE approach, which integrates successful replication of the association with clinical and experimental evidence. For replication studies, gene–phenotype associations were evaluated for their robustness by interrogating REVEL-informed missense-based gene burdens and single variants in the same discovery PMBB cohort, and pLOF-based gene burdens, REVEL-informed missense-based gene burdens and single variants in an independent cohort of African Americans in the PMBB (the PMBB2 cohort), as well as in BioMe, DiscovEHR and the UKB. Targeted single variants that showed successful replication in the PMBB, PMBB2 and UKB were additionally analyzed in BioVU. Each gene–phecode association is labeled with the corresponding P value from logistic regression analyses in the discovery phase in the PMBB, as well as the number of total replications and existence of clinical/experimental evidence, fully detailed in Supplementary Table 17 . Only associations with at least two total check marks in Supplementary Table 17 , where each successful mode of replication in a particular biobank (for example, pLOF burden in BioMe) or the existence of clinical/experimental evidence is labeled with a checkmark, were deemed robust and therefore included here. Previously known associations were considered to represent positive controls. Positive control (above line) and new associations (below line) are each ranked alphabetically by gene name.

Article Snippet: 54 Immunolocalization of PPP1R13L in human retina To study the localization of PPP1R13L protein in different retinal layers of the human eye, we performed immunofluorescence on formalin-fixed paraffin-embedded section (N=3) obtained from normal 68-year old donor’s cadaver eyes with a commercially available antibody, anti-PPP1R13L (Cat# 51141-1-AP, Proteintech, IL, USA).

Techniques: Labeling, Positive Control, Coagulation

A) Differential expression profile of Ppp1r13l transcript in mouse optic nerve head (ONH) with varying stages of intraocular pressure (IOP)-induced glaucoma. Data represent the fold change in Ppp1r13l expression between different stages of D2 mice (glaucoma, N=50 mice) and D2 Gpnmb+ samples (control, N=10 mice). B) Localization of PPP1R13L protein in the human retina. Shown is the distribution of PPP1R13L by immunohistochemical localization in the retina from normal 68-year-old donor eyes. Overlay of images from DAPI (blue; nuclei) and PPP1R13L (red) in adult human retinal layers are shown on the right. The left represents primary antibody control. Scale bars are shown in each image. The experiment was performed twice independently with consistent results. ONL, outer nuclear layer; OPL, outer plexiform layer; IPL, inner plexiform layer; GCL, ganglion cell layer. C) Relative expression of PPP1R13L transcript in response to oxidative stress in induced pluripotent stem cell-derived retinal ganglion cells (iPSC-RGCs). A two-tailed unpaired Student’s t test was used for statistical analysis, and significant p values are shown. Expression of PPP1R13L in iPSC-RGCs is shown under increasing concentrations of H2O2 treatment (N=3 independent experiments per condition). Plotted are the mean fold changes in comparison to no H2O2, error bars represent standard error of the mean (SEM), and individual values are plotted overlaying the bar plot.

Journal: Nature medicine

Article Title: Exome-wide evaluation of rare coding variants using electronic health records identifies new gene-phenotype associations

doi: 10.1038/s41591-020-1133-8

Figure Lengend Snippet: A) Differential expression profile of Ppp1r13l transcript in mouse optic nerve head (ONH) with varying stages of intraocular pressure (IOP)-induced glaucoma. Data represent the fold change in Ppp1r13l expression between different stages of D2 mice (glaucoma, N=50 mice) and D2 Gpnmb+ samples (control, N=10 mice). B) Localization of PPP1R13L protein in the human retina. Shown is the distribution of PPP1R13L by immunohistochemical localization in the retina from normal 68-year-old donor eyes. Overlay of images from DAPI (blue; nuclei) and PPP1R13L (red) in adult human retinal layers are shown on the right. The left represents primary antibody control. Scale bars are shown in each image. The experiment was performed twice independently with consistent results. ONL, outer nuclear layer; OPL, outer plexiform layer; IPL, inner plexiform layer; GCL, ganglion cell layer. C) Relative expression of PPP1R13L transcript in response to oxidative stress in induced pluripotent stem cell-derived retinal ganglion cells (iPSC-RGCs). A two-tailed unpaired Student’s t test was used for statistical analysis, and significant p values are shown. Expression of PPP1R13L in iPSC-RGCs is shown under increasing concentrations of H2O2 treatment (N=3 independent experiments per condition). Plotted are the mean fold changes in comparison to no H2O2, error bars represent standard error of the mean (SEM), and individual values are plotted overlaying the bar plot.

Article Snippet: 54 Immunolocalization of PPP1R13L in human retina To study the localization of PPP1R13L protein in different retinal layers of the human eye, we performed immunofluorescence on formalin-fixed paraffin-embedded section (N=3) obtained from normal 68-year old donor’s cadaver eyes with a commercially available antibody, anti-PPP1R13L (Cat# 51141-1-AP, Proteintech, IL, USA).

Techniques: Functional Assay, Biomarker Discovery, Quantitative Proteomics, Expressing, Control, Immunohistochemical staining, Derivative Assay, Two Tailed Test, Comparison